1360932-70-2

Upstream product

• 276880-05-8 2,6-dimethoxy-4-[(1,1-dimethylethyl)diphenylsilyloxymethyl]benzaldehyde 
• 115130-81-9 (1,1-dimethylethyl)diphenylsilyl 3,5-dimethoxybenzyl ether 
• 1132-21-4 3,5-dimethoxybenzoic acid 
• 705-76-0 3,5-dimethoxybenzyl alcohol 
• 1360933-04-5 C₃₂H₃₈O₅Si 
• 1360933-03-4 C₃₂H₃₆O₅Si 
• 1360932-68-8 C₃₂H₃₈O₆Si 
• 1360932-61-1 C₃₀H₃₆O₅Si 
• 1360932-63-3 C₃₀H₃₄O₄Si 

Downstream Products

• 1360933-05-6 C₃₁H₃₄O₆Si 

Relevant academic research and scientific papers

A unified strategy for the asymmetric total syntheses of diversonol and lachnone C

A unified synthetic strategy for the asymmetric syntheses of the natural products diversonol and lachnone C was developed by using the domino vinylogous aldol-oxa-Michael reaction as the enantioselective key step. Further transformations include dihydroxylation, lactol-opening by a Wittig-reaction, and lactonization. The obtained chromone lactones, a class of mycotoxins, can further be converted to tetrahydroxanthones by a Dieckmann condensation. This general method allows for the first time the enantioselective access to these classes of natural products and should be applicable to other members of the tetrahydroxanthone and chromone lactone families. Cohesive synthetic strategy: The first asymmetric total syntheses of mycotoxins (+)-lachnone C and (-)-diversonol were achieved with the enantioselective domino vinylogous aldol-oxa-Michael reaction as the key step (see scheme).