1361017-75-5Relevant academic research and scientific papers
Palladium-catalysed ring-opening [3 + 2]-annulation of spirovinylcyclopropyl oxindole to diastereoselectively access spirooxindoles
Xiao, Jun-An,Cheng, Xiu-Liang,Li, Yu-Chun,He, Yi-Miao,Li, Jin-Lian,Liu, Zhi-Ping,Su, Wei,Xia, Peng-Ju,Yang, Hua
, p. 103 - 107 (2019)
A novel palladium-catalysed ring-opening [3 + 2]-annulation of spirovinylcyclopropyl oxindole with α,β-unsaturated nitroalkenes is reported. A series of spirooxindole derivatives were synthesized in high yields and good to excellent diastereoselectivities. This developed protocol offers a new and efficient pathway for the assembly of spirooxindoles.
Enantioselective Synthesis of Multisubstituted Spirocyclopentane Oxindoles Enabled by Pd/Chiral Rh(III) Complex Synergistic Catalysis
Wan, Qian,Chen, Liang,Li, Shiwu,Kang, Qiang,Yuan, Yaofeng,Du, Yu
supporting information, p. 9539 - 9544 (2020/12/21)
An asymmetric [3 + 2]-cycloaddition reaction of α,β-unsaturated 2-acyl imidazoles with spirovinylcyclopropanyl-2-oxindoles catalyzed synergistically by an achiral palladium(0) catalyst and a chiral-at-metal rhodium(III) complex has been developed. A series of biologically important 3-spirocyclopentane-2-oxindoles with four contiguous stereocenters were synthesized in high yields (up to 99%) with excellent stereoselectivities (up to 99% ee, 20:1 dr).
Construction of Bispirooxindole Heterocycles via Palladium-Catalyzed Ring-Opening Formal [3 + 2]-Cycloaddition of Spirovinylcyclopropyl Oxindole and 3-Oxindole Derivatives
Xiao, Jun-An,Li, Yu-Chun,Luo, Zhi-Jin,Cheng, Xiu-Liang,Deng, Zhi-Xiong,Chen, Wen-Qiang,Su, Wei,Yang, Hua
, (2019/02/14)
A palladium-catalyzed ring-opening oxo-formal [3 + 2]-cycloaddition reaction of novel donor-acceptor spirovinylcyclopropyl oxindole with 3-oxindole is described. The developed protocol provides facile access to oxo-bispirooxindole derivatives in good yields (up to 82% yield) with excellent diastereoselectivities (up to 20:1 dr).
