1361019-89-7Relevant academic research and scientific papers
A simple and efficient stereoselective synthesis of (-)-cleistenolide
Vijaya Kumar,Suresh Babu,Madhusudana Rao
, p. 1823 - 1825 (2012/05/04)
A simple and straightforward stereoselective synthesis of α,β-unsaturated δ-lactone, (-)-cleistenolide has been accomplished in 10 steps in an overall yield of 19%, starting from inexpensive and commercially available starting materials, respectively. This linear synthesis utilizes Sharpless asymmetric dihydroxylation, sulfur ylide mediated epoxide opening followed by ring-closing metathesis (RCM) for the formation of six-membered lactone ring as the key step sequence.
