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LDC1267 is a chemical compound that functions as a selective inhibitor of the enzyme autotaxin, which plays a crucial role in lipid metabolism and the synthesis of lysophosphatidic acid (LPA). LPA is a bioactive lipid associated with various biological processes such as cell proliferation, migration, and inflammation. By inhibiting autotaxin, LDC1267 can potentially regulate LPA levels, influencing these biological processes. It has shown therapeutic potential in treating fibrotic disorders, cancer, and inflammatory conditions and has demonstrated promising results in preclinical studies, making it a valuable tool for further research into the role of autotaxin and LPA in disease pathogenesis.

1361030-48-9

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1361030-48-9 Usage

Uses

Used in Pharmaceutical Industry:
LDC1267 is used as a therapeutic agent for the treatment of fibrotic disorders, cancer, and inflammatory conditions due to its ability to modulate LPA levels, which are implicated in these diseases.
Used in Research Applications:
LDC1267 is used as a research tool for investigating the role of autotaxin and LPA in disease pathogenesis, providing insights into the development of new therapeutic strategies targeting these pathways.

Check Digit Verification of cas no

The CAS Registry Mumber 1361030-48-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,6,1,0,3 and 0 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1361030-48:
(9*1)+(8*3)+(7*6)+(6*1)+(5*0)+(4*3)+(3*0)+(2*4)+(1*8)=109
109 % 10 = 9
So 1361030-48-9 is a valid CAS Registry Number.

1361030-48-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name N-[4-[(6,7-dimethoxy-4-quinolyl)oxy]-3-fluoro-phenyl]-4-ethoxy-1-(4-fluoro-2-methyl-phenyl)pyrazole-3-carboxamide

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1361030-48-9 SDS

1361030-48-9Upstream product

1361030-48-9Downstream Products

1361030-48-9Relevant academic research and scientific papers

PHARMACEUTICALLY ACTIVE COMPOUNDS AS AXL INHIBITORS

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Page/Page column 89, (2012/03/26)

The present invention relates to 1-nitrogen-heterocyclic-2-carboxamides of general formula (I): and/or pharmaceutically acceptable salts thereof, the use of these derivatives as pharmaceutically active agents, especially for the treatment and/or prevention of Axl receptor tyrosine kinase subfamily induced disorders, including cancer and primary tumor metastases, and pharmaceutical compositions containing at least one of said 1-nitrogen-heterocyclic-2-carboxamide derivatives and/or pharmaceutically acceptable salts thereof.

Pharmaceutically active compounds as Axl inhibitors

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Paragraph 0093, (2013/03/26)

The present invention relates to 1-nitrogen-heterocyclic-2-carboxamides of general formula (I): and/or pharmaceutically acceptable salts thereof, the use of these derivatives as pharmaceutically active agents, especially for the treatment and/or prevention of Axl receptor tyrosine kinase subfamily induced disorders, including cancer and primary tumor metastases, and pharmaceutical compositions containing at least one of said 1-nitrogen-heterocyclic-2-carboxamide derivatives and/or pharmaceutically acceptable salts thereof.

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