1361050-70-5

Upstream product

• 327-52-6 1-bromo-2,4,5-trifluorobenzene 
• 1361050-69-2 4-methoxy-4-oxo-2-(2,4,5-trifluorobenzyl)butanoic acid 
• 1361050-65-8 (E)-1-benzyl-4-methyl-2-(2,4,5-trifluorobenzylidene)succinate 
• 7338-27-4 4-methoxy-2-methylene-4-oxobutanoic acid 
• 24345-85-5 1-benzyl-4-methyl itaconate 

Downstream Products

• 1361050-74-9 (R)-methyl-3-(isopropoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoate 
• 1361050-75-0 methyl (R)-3-(((benzyloxy)carbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoate 
• 881995-73-9 3-(R)-tert-butoxycarbonylamino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester 
• 486460-00-8 (3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid 
• 486460-23-5 (R)-tert-butyl 4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-ylcarbamate 
• 1361050-76-1 (R)-3-(isopropoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoic acid 
• 1361050-77-2 (R)-isopropyl-4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-yl-carbamate 

Relevant academic research and scientific papers

Sitagliptin intermediate preparation method

The invention relates to the technical field of organic chemistry and especially relates to a sitagliptin intermediate preparation method. The invention provides a compound with a structure shown in the formula 6. The sitagliptin intermediate shown in the formula 8 and prepared from the compound with a structure shown in the formula 6 has high HPLC purity and an ee value of 99% or more.

Process for the production of sitagliptin

The present invention is directed to a process for the preparation of Sitagliptin, having formula (I)