136107-94-3

Basic information

• Product Name: ANNEXIN V
• Synonyms: LIPOCORTIN V;ANNEXIN V (HUMAN);ANNEXIN V, HUMAN, RECOMBINANT;ANNEXIN V;CALPHOSBINDIN I;PAP-1;Annexin V Cy3.18 Conjugate from human placenta;Annexin V Biotin Conjugate from human placenta
• CAS NO: 136107-94-3
• Molecular Formula: C21H18O5
• Molecular Weight: 0
• Mol File: 136107-94-3.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: ANNEXIN V(CAS DataBase Reference)
• NIST Chemistry Reference: ANNEXIN V(136107-94-3)
• EPA Substance Registry System: ANNEXIN V(136107-94-3)

Safety Data

• Statements: 42/43
• Safety Statements: 22-36/37-45
• WGK Germany: 3
• Hazardous Substances Data: 136107-94-3(Hazardous Substances Data)

Usage

Uses

For detection of apoptotic cells by flow cytometry or fluorescence microscopy.

Biochem/physiol Actions

Annexins are ubiquitous homologous proteins that bind phospholipids in the presence of calcium. The cellular changes involved in the apoptotic process include loss of phospholipid asymmetry during the early stages. This phenomenon is universal and is not limited to stimulus or to mammalian cells, but also occurs in insect and plant cells. In living cells, phosphatidylserine is transported to the inside of the lipid bilayer by the Mg2+ATP dependent enzyme, aminophospholipid translocase. At the onset of apoptosis, phosphatidylserine becomes translocated to the external surface of the cell membrane. Since the movement of phosphatidylserine from the internal membrane surface to the external surface is an early indicator of apoptosis, annexin V and its conjugates that interact strongly and specifically with phosphatidylserine may be used to detect apoptosis. Annexin V conjugates can be used to detect apoptotic cells significantly earlier than DNA-based assays. Fluorescent dye labeled annexin V have applications in flow cytometry, fluorescence microscopy, and laser scanning cytometry.

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