Heat shock factor 1 (HSF1) is a transcription factor that plays a pivotal role in the cellular response to stress, particularly heat shock. It is responsible for regulating the expression of heat shock proteins, which protect cells from the damaging effects of stress. HSF1 is activated in response to various stressors, such as high temperatures, oxidative stress, and viral infection. Upon activation, HSF1 upregulates the expression of heat shock proteins that act as molecular chaperones to maintain protein homeostasis and cell survival under stress conditions. Dysfunction of HSF1 has been associated with various diseases, including cancer and neurodegenerative disorders, highlighting its importance as a target for therapeutic interventions.
136111-36-9
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Basic information
- Product Name: heat shock factor, human
- Synonyms: heat shock factor, human
- CAS NO:136111-36-9
- Molecular Formula:
- Molecular Weight: 0
- EINECS: N/A
- Product Categories: N/A
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- CAS DataBase Reference: heat shock factor, human(CAS DataBase Reference)
- NIST Chemistry Reference: heat shock factor, human(136111-36-9)
- EPA Substance Registry System: heat shock factor, human(136111-36-9)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 136111-36-9(Hazardous Substances Data)
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136111-36-9 Usage
Uses
Used in Pharmaceutical Industry:Heat shock factor 1 (HSF1) is used as a therapeutic target for the development of drugs that modulate its activity to treat various diseases. The activation or inhibition of HSF1 can help restore protein homeostasis and cell survival under stress conditions, making it a promising target for the treatment of diseases associated with HSF1 dysfunction, such as cancer and neurodegenerative disorders.
Used in Research Applications:
HSF1 is used as a research tool to study the molecular mechanisms of cellular stress response and the role of heat shock proteins in maintaining protein homeostasis and cell survival. It is also used to investigate the role of HSF1 in the pathogenesis of various diseases and to identify potential therapeutic targets for intervention.
Used in Drug Screening and Development:
HSF1 is used in drug screening and development to identify compounds that can modulate its activity and potentially treat diseases associated with HSF1 dysfunction. High-throughput screening assays and other experimental approaches can be employed to evaluate the efficacy and safety of these compounds in modulating HSF1 activity and their potential therapeutic benefits.
Used in Diagnostic Applications:
HSF1 can be used as a biomarker for the diagnosis and prognosis of diseases associated with its dysfunction. The measurement of HSF1 expression levels or activity in biological samples can provide valuable information about the disease status and help guide therapeutic decisions.
Used in Gene Therapy:
HSF1 can be used as a target for gene therapy approaches to treat diseases associated with its dysfunction. The delivery of functional HSF1 or its regulatory elements into cells can help restore its normal activity and potentially alleviate the disease phenotype.
Check Digit Verification of cas no
The CAS Registry Mumber 136111-36-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,6,1,1 and 1 respectively; the second part has 2 digits, 3 and 6 respectively.Calculate Digit Verification of CAS Registry Number 136111-36:
(8*1)+(7*3)+(6*6)+(5*1)+(4*1)+(3*1)+(2*3)+(1*6)=89
89 % 10 = 9
So 136111-36-9 is a valid CAS Registry Number.
136111-36-9Upstream product
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heat shock factor, human
