1361131-95-4

Upstream product

• 766-97-2 4-n-methylphenylacetylene 
• 321534-83-2 methyl 2-(4-methylphenethyl)benzoate 
• 118520-72-2 methyl 2-[(4-methylphenyl)ethynyl]benzoate 
• 17763-70-1 methyl 2-(trifluoromethylsulfonyloxy)benzoate 
• 1361131-94-3 C₁₆H₁₈O 

Downstream Products

• 1361132-04-8 C₂₂H₂₂N₂O₃ 
• 1363394-45-9 3-p-tolyl-2-tosyl-1,2,3,4-tetrahydroisoquinoline 

Relevant academic research and scientific papers

Concise route to 3-arylisoquinoline skeleton by lewis acid catalyzed c(sp3)-h bond functionalization and its application to formal synthesis of (±)-Tetrahydropalmatine

An expeditious route to furnish an isoquinoline skeleton via hydride shift mediated C-H bond functionalization was developed. In this process, an unusual [1,5]-H shift without the assistance of the adjacent heteroatom took place to produce tetrahydroisoquinoline derivatives in good to excellent chemical yields. The formal synthesis of (±)-tetrahydropalmatine was achieved by exploiting this new transformation.

Rapid access to 3-aryltetralin skeleton via C(sp3)-H bond functionalization: Investigation on the substituent effect of aromatic ring adjacent to C-H bond in hydride shift/cyclization sequence

The concise construction of 3-aryltetralin skeleton via hydride shift mediated C-H bond functionalization was achieved. In this process, the benzylic [1,5]-H shift occurred smoothly to furnish tetralin derivatives in good to excellent chemical yields. The electronic and steric properties of the aromatic ring adjacent to the C-H bond influenced significantly the reactivity of this transformation.