1361144-02-6Relevant academic research and scientific papers
Facile N-urethane-protected α-amino/peptide thioacid preparation using EDC and Na2S
Vishwanatha,Samarasimhareddy,Sureshbabu, Vommina V.
, p. 89 - 92 (2012)
We report herein an efficient protocol for the synthesis of N-urethane-protected α-amino/peptide thioacids from their corresponding acids mediated by EDC and Na2S. The fast reaction under mild conditions enabled the process to be completed in shorter duration with good yield circumventing column purification. The chemistry is compatible with a wide variety of urethane protecting groups, side-chain functionalities, and sterically hindered amino -acids. Georg Thieme Verlag Stuttgart. New York.
