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1361147-77-4

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1361147-77-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1361147-77-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,6,1,1,4 and 7 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1361147-77:
(9*1)+(8*3)+(7*6)+(6*1)+(5*1)+(4*4)+(3*7)+(2*7)+(1*7)=144
144 % 10 = 4
So 1361147-77-4 is a valid CAS Registry Number.

1361147-77-4Relevant academic research and scientific papers

Discovery of SCH 900188: A potent hepatitis C virus NS5B polymerase inhibitor prodrug as a development candidate

Chen, Kevin X.,Venkatraman, Srikanth,Anilkumar, Gopinadhan N.,Zeng, Qingbei,Lesburg, Charles A.,Vibulbhan, Bancha,Velazquez, Francisco,Chan, Tin-Yau,Bennet, Frank,Jiang, Yueheng,Pinto, Patrick,Huang, Yuhua,Selyutin, Oleg,Agrawal, Sony,Huang, Hsueh-Cheng,Li, Cheng,Cheng, Kuo-Chi,Shih, Neng-Yang,Kozlowski, Joseph A.,Rosenblum, Stuart B.,Njoroge, F. George

, p. 244 - 248 (2014/04/03)

Starting from indole-based hepatitis C virus (HCV) NS5B polymerase inhibitor lead compound 1, structure modifications were performed at multiple indole substituents to improve potency and pharmacokinetic (PK) properties. Bicyclic quinazolinone was found to be the best substituent at indole nitrogen, while 4,5-furanylindole was identified as the best core. Compound 11 demonstrated excellent potency. Its C2 N,N-dimethylaminoethyl ester prodrug 12 (SCH 900188) demonstrated significant improvement in PK and was selected as the development candidate.

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