1361151-79-2

Upstream product

• 3972-65-4 1-bromo-4-tert-butylbenzene 
• 854401-91-5 methyl 5-(naphthalen-1-yl)furan-2-carboxylate 
• 90-11-9 1-Bromonaphthalene 
• 115933-43-2 methyl 5-(4-tert-butylphenyl)furan-2-carboxylate 

Relevant academic research and scientific papers

Methyl 2-furoate: An alternative reagent to furan for palladium-catalysed direct arylation

The palladium-catalysed direct arylation of methyl 2-furoate with aryl bromides was studied. The use of KOAc as the base, dimethylacetamide (DMAc) as the solvent and Pd(OAc)2 as the catalyst was found to give 5-arylfurans regioselectively and without decarboxylation. These methyl 5-aryl-2-furoates gave 2,5-diarylfurans by decarboxylative coupling by using Pd(OAc)2 as the catalyst. Methyl 2-furoate thus represents a convenient alternative substrate to furan for the synthesis of mono- or poly-arylated furans.