136117-46-9 Usage
Uses
Used in Pharmaceutical Research and Drug Development:
5-Acetyl-3-bromo-6-methyl-2(1H)-pyridinone is used as a research compound for exploring its potential biological activities, including its antiviral, antimicrobial, and antitumor properties. Its unique structure and properties make it an interesting target for the development of new therapeutic agents for a range of diseases.
Used in Antiviral Applications:
In the field of antiviral research, 5-Acetyl-3-bromo-6-methyl-2(1H)-pyridinone is used as a potential therapeutic agent to combat viral infections. Its antiviral properties are being studied to understand its mechanism of action and to develop it into an effective treatment for various viral diseases.
Used in Antimicrobial Applications:
5-Acetyl-3-bromo-6-methyl-2(1H)-pyridinone is also used as an antimicrobial agent, where it is being investigated for its ability to inhibit the growth of bacteria and other microorganisms. This research aims to develop new antibiotics or antimicrobial drugs to address the growing issue of antibiotic resistance.
Used in Antitumor Applications:
In cancer research, 5-Acetyl-3-bromo-6-methyl-2(1H)-pyridinone is used as a potential antitumor agent. Its antitumor properties are being studied to understand how it may inhibit tumor growth and progression, with the goal of developing new cancer therapies.
Used in Medicinal Chemistry:
5-Acetyl-3-bromo-6-methyl-2(1H)-pyridinone is used as a target compound in medicinal chemistry for further research and development. Its unique structure and potential biological activities make it an attractive candidate for the design and synthesis of new drugs with improved efficacy and selectivity.
Check Digit Verification of cas no
The CAS Registry Mumber 136117-46-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,6,1,1 and 7 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 136117-46:
(8*1)+(7*3)+(6*6)+(5*1)+(4*1)+(3*7)+(2*4)+(1*6)=109
109 % 10 = 9
So 136117-46-9 is a valid CAS Registry Number.
136117-46-9Relevant academic research and scientific papers
AN EFFICIENT AND NOVEL SYNTHESIS OF FUSED THIAZOL-2(3H)-ONES
Singh, Baldev,Pennock, Patrick O.,Lesher, George Y.,Bacon, Edward R.,Page, Donald F.
, p. 133 - 144 (2007/10/02)
Reaction of o-bromo aromatic amines (2, 4, 7, 10, 15) with ethyl potassium xanthate gave the corresponding fused thiazol-2(3H)-thiones (16, 19, 22) which in turn were first alkylated with methyl iodide and then treated with sodium methoxide to produce fus
Imidazo[1,2-a]pyridines. Synthesis and inotropic activity of new 5-imidazo[1,2-a]pyridinyl-2(1H)-pyridinone derivatives
Yamanaka,Miyake,Suda,Ohhara,Ogawa
, p. 1556 - 1567 (2007/10/02)
A series of 1,2-dihydro-5-imidazo[1,2-a]pyridinyl-2(1H)-pyridinones was synthesized and evaluated for positive inotropic activity. 1,2-Dihydro-5-imidazo[1,2-a]pyridin-6-yl-6-methyl-2-oxo-3- pyridinecarbonitrile (11a) hydrochloride monohydrate (E-1020) was found to be a potent and selective inhibitor of phosphodiesterase III and a long-acting, potent, orally active positive inotropic agent. Additional imidazo[1,2-a]pyridin-2-yl (3a), -3-yl (16), -7-yl (20) and -8-yl (24a) compounds were also prepared. Altering the pyridine substitution from the 2-position to the 6-position produced a 2-fold increase in the i.v. cardiotonic potency (ED50) from 52 to 23 μg/kg, while substitution at the 3-, 7- or 8-position reduced potency. In the 2-positional isomers, introduction of halogen groups enhanced the activity and 3-chloro-1,2-dihydro-5-(6-fluoroimidazo[1,2-a]pyridin-2-yl)-6-methyl-2(1H)- pyridinone (3a) was the most potent (i.v. ED50 11 μg/kg) in this seris. E-1020 is presently under development for the treatment of congestive heart failure.
