1361252-69-8Relevant academic research and scientific papers
SELECTIVE 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS
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Page/Page column 81, (2012/03/26)
The invention relates to selective, non-steroidal 17beta-hydroxysteroid dehydrogenase type 1 (17β-HSD1) inhibitors their production and use, especially for the treatment and/or prophylaxis of hormone-related diseases.
Bicyclic Substituted Hydroxyphenylmethanone Type Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type1 (17β-HSD1): The Role of the Bicyclic Moiety
Oster, Alexander,Klein, Tobias,Henn, Claudia,Werth, Ruth,Marchais-Oberwinkler, Sandrine,Frotscher, Martin,Hartmann, Rolf W.
, p. 476 - 487 (2012/01/03)
An attractive target that has still to be explored for the treatment of estrogen-dependent diseases, such as breast cancer and endometriosis, is the enzyme responsible for the last step in the biosynthesis of estradiol (E2): 17β-hydroxysteroid dehydrogena
