1361253-19-1

Basic information

• Product Name: 4-fluoro-3-methoxy-N-(6-methoxy-1,3-benzothiazol-2-yl)benzamide
• Synonyms: 4-fluoro-3-methoxy-N-(6-methoxy-1,3-benzothiazol-2-yl)benzamide
• CAS NO: 1361253-19-1
• Molecular Weight: 332.355
• Mol File: 1361253-19-1.mol

Chemical Properties

• CAS DataBase Reference: 4-fluoro-3-methoxy-N-(6-methoxy-1,3-benzothiazol-2-yl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-fluoro-3-methoxy-N-(6-methoxy-1,3-benzothiazol-2-yl)benzamide(1361253-19-1)
• EPA Substance Registry System: 4-fluoro-3-methoxy-N-(6-methoxy-1,3-benzothiazol-2-yl)benzamide(1361253-19-1)

Safety Data

• Hazardous Substances Data: 1361253-19-1(Hazardous Substances Data)

Upstream product

• 1747-60-0 6-methoxybenzothiazol-2-ylamine 
• 82846-19-3 4-fluoro-3-methoxybenzoyl chloride 

Downstream Products

• 1361253-20-4 4-fluoro-3-methoxy-N-(6-methoxy-1,3-benzothiazol-2-yl)-N-methylbenzamide 
• 1361252-84-7 4-fluoro-3-hydroxy-N-(6-hydroxy-1,3-benzothiazol-2-yl)benzamide 
• 1361252-85-8 4-fluoro-3-hydroxy-N-(6-hydroxy-1,3-benzothiazol-2-yl)-N-methylbenzamide 

Relevant articles and documents

SELECTIVE 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS

The invention relates to selective, non-steroidal 17beta-hydroxysteroid dehydrogenase type 1 (17β-HSD1) inhibitors their production and use, especially for the treatment and/or prophylaxis of hormone-related diseases.

Optimization of hydroxybenzothiazoles as novel potent and selective inhibitors of 17β-HSD1

17β-HSD1 is a novel target for the treatment of estrogen-dependent diseases, as it catalyzes intracellular estradiol formation. Starting from two recently described compounds, highly active and selective inhibitors were developed. Benzoyl 6 and benzamide 17 are the most selective compounds toward 17β-HSD2 described so far. They also showed a promising profile regarding activity in T47-D cells, selectivity toward ERα and ERβ, inhibition of hepatic CYP enzymes, metabolic stability, and inhibition of marmoset 17β-HSD1 and 17β-HSD2.