1361321-06-3Relevant academic research and scientific papers
A multimetallic piano-stool Ir-Sn3 catalyst for nucleophilic substitution reaction of γ-hydroxy lactams through N -acyliminium ions
Maity, Arnab Kumar,Roy, Sujit
experimental part, p. 2935 - 2941 (2012/05/20)
A multimetallic piano-stool complex [Cp*Ir(SnCl3) 2{SnCl2(H2O)2}] (1) having Ir-Sn3 motif has been synthesized from [Cp*IrCl 2]2 and SnCl2. The multimetallic complex catalytically promotes the nucleophilic substitution reaction (here after α-amidoalkylation reaction) of γ-hydroxylactams generated from phthalimidals to obtain decorated isoindolinones in excellent yields. Succinamidals, however, lead to the substituted pyrrolidinones (thermodynamic control product) via SN1-type path as well as eliminated pyrrolinones (kinetic control product) via an E1-type path, depending on the reaction parameters. A straightforward application of this methodology is to synthesize benzo-fused indolizidine alkaloid mimics.
