1361321-08-5Relevant academic research and scientific papers
PdII/AgI-Catalyzed Room-Temperature Reaction of γ-Hydroxy Lactams: Mechanism, Scope, and Antistaphylococcal Activity
Dutta, Manali,Mandal, Santi M.,Pegu, Rupa,Pratihar, Sanjay
, p. 2193 - 2198 (2017/03/01)
The present work reports a PdII/AgI-promoted amidoalkylation reaction involving various γ-hydroxy lactams and C/O/S nucleophiles at room temperature. The dual mode of activation of both the electrophile and nucleophile by in situ generated catalytically active cationic PdII species facilitates the reaction at room temperature. Among the synthesized isoindoline derivatives, three compounds are found to be active against vancomycin and methicillin-resistant S. aureus strain with appreciable MIC values.
A multimetallic piano-stool Ir-Sn3 catalyst for nucleophilic substitution reaction of γ-hydroxy lactams through N -acyliminium ions
Maity, Arnab Kumar,Roy, Sujit
experimental part, p. 2935 - 2941 (2012/05/20)
A multimetallic piano-stool complex [Cp*Ir(SnCl3) 2{SnCl2(H2O)2}] (1) having Ir-Sn3 motif has been synthesized from [Cp*IrCl 2]2 and SnCl2. The multimetallic complex catalytically promotes the nucleophilic substitution reaction (here after α-amidoalkylation reaction) of γ-hydroxylactams generated from phthalimidals to obtain decorated isoindolinones in excellent yields. Succinamidals, however, lead to the substituted pyrrolidinones (thermodynamic control product) via SN1-type path as well as eliminated pyrrolinones (kinetic control product) via an E1-type path, depending on the reaction parameters. A straightforward application of this methodology is to synthesize benzo-fused indolizidine alkaloid mimics.
