1361327-63-0Relevant academic research and scientific papers
Method for inhibiting Trypanosoma cruzi
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Page/Page column 22; 23; 24, (2016/09/26)
Methods are provided to inhibit proliferation of Trypanosoma cruzi with imido-substituted 1,4-naphthoquinones, including novel compounds. Administering an imido-substituted 1,4-naphthoquinone can be used to provide prophylaxis or treatment to a patient in
METHOD FOR INHIBITING TRYPANSOMA CRUZI
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Paragraph 27; 28; 29; 30, (2013/03/26)
In its broadest aspect, a method for treating a mammalian patient at risk or suffering from a disease caused by a kinetoplastid parasite comprises administering to such subject an effective kinetoplasticidal amount of an imido-substituted 1,4- naphthoquin
METHODS FOR TREATING LEISHMANIASIS
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Page/Page column 27, (2013/06/05)
Methods are provided to inhibit proliferation of Leishmania parasites, and in particular Leishmania donovani with imido-substituted 1,4-naphthoquinones, including novel compounds. Administering an imido-substituted 1,4-naphthoquinone can be used to provide prophylaxis or treatment to a patient in need of treatment against leishmaniasis disease.
Synthesis and characterization of novel unsymmetrical and symmetrical 3-halo- or 3-methoxy-substituted 2-dibenzoylamino-1,4-naphthoquinone derivatives
Brandy, Yakini,Brandy, Nailah,Akinboye, Emmanuel,Lewis, Malik,Mouamba, Claudia,MacK, Seshat,Butcher, Ray J.,Anderson, Alan J.,Bakare, Oladapo
, p. 1973 - 1984 (2013/04/10)
Symmetrical and unsymmetrical 3-halo- or 3-methoxy- substituted 2-dibenzoylamino- 1,4-naphthoquinone analogs were synthesized with an average yield of 45% via sodium hydride promoted bis-acylation of 2-amino-3-chloro-1,4- naphthoquinone, 2-amino-3-bromo- 1,4-naphthoquinone and 2-amino-3-methoxy-1,4- naphthoquinone.
Antitrypanosomal activities and cytotoxicity of some novel imidosubstituted 1,4-naphthoquinone derivatives
Khraiwesh, Mozna H.,Lee, Clarence M.,Brandy, Yakini,Akinboye, Emmanuel S.,Berhe, Solomon,Gittens, Genelle,Abbas, Muneer M.,Ampy, Franklin R.,Ashraf, Mohammad,Bakare, Oladapo
experimental part, p. 27 - 33 (2012/07/02)
The antitrypanosomal activities, cytotoxicity, and selectivity indices of eleven imido-substituted 1,4-naphthoquinone derivatives and nifurtimox have been studied. Compared to nifurtimox (IC50 = 10.67 μM), all the imido-naphthoquinone analogs (
