1361345-91-6Relevant academic research and scientific papers
Control of Enantioselectivity in Rhodium(I) Catalysis by Planar Chiral Dibenzo[a,e]cyclooctatetraenes
Melcher, Michaela-Christina,Iv?i?, Trpimir,Olagnon, Charlotte,Tenten, Christina,Lützen, Arne,Strand, Daniel
supporting information, p. 2344 - 2348 (2017/12/26)
Planar chiral 5,11-disubstiuted dibenzo[a,e]cyclo-octatetraenes (dbCOTs) have been developed as the first useful chiral homologs to dbCOT-ligands for asymmetric applications. Methods enabling the preparation of such compounds on a gram-scale in enantiomerically pure form are described. Evaluated as ligands in rhodium(I)-catalyzed 1,4- and 1,2-arylation reactions, tertiary and quarternary stereogenic centers were formed with excellent yields and selectivities of up to >99 % ee. A catalytic asymmetric synthesis of a key cyclization precursor to (?)-penifulvin A highlights the system in an applied context.
Rhodium-catalyzed, highly enantioselective 1,2-addition of aryl boronic acids to α-ketoesters and α-diketones using simple, chiral sulfur-olefin ligands
Zhu, Ting-Shun,Jin, Shen-Shuang,Xu, Ming-Hua
scheme or table, p. 780 - 783 (2012/02/06)
Simply the best: The title reaction has been achieved by asymmetric rhodium catalysis employing an extremely simple, chiral N-(sulfinyl)cinnamylamine ligand. A variety of highly enantioenriched, tertiary α-hydroxy carbonyl derivatives were easily accessed
