136136-92-0Relevant academic research and scientific papers
ALKYLATION AND REDUCTION REACTIONS IN THE ISOQUINOQUINAZOLINE SERIES
Kisel', V. M.,Kovtunenko, V. A.,Turov, A. V.,Tyltin, A. K.,Babichev, F. S.
, p. 316 - 321 (1991)
Protonation and methylation of 5-oxo-7,12-dihydro-5H-isoquinoquinazoline occur at the N(6) atom, while methylation of 5-oxo- and 6-methyl-5-oxo-6,6a,7,12-tetrahydro-5H-isoquinoquinazolines takes place at the N(13) atom; the degree of stereoselectivity varies depending on the presence of a substituent attached to N(13).Based on PMR spectral analysis utilizing the nuclear Overhauser effect, we have established the structure and studied the conformational behavior of the tosylate derivatives of cis-13-methyl-, trans-13-methyl-, and cis-6,13-dimethyl-5-oxo-6,6a,7,12-tetrahydro-5H-isoquinoquinazolinium ions.
