1361391-03-8Relevant academic research and scientific papers
Versatile enantioselective [3+2] cyclization between imines and allenoates catalyzed by dipeptide-based phosphines
Han, Xiaoyu,Zhong, Fangrui,Wang, Youqing,Lu, Yixin
supporting information; experimental part, p. 767 - 770 (2012/03/09)
A fast one: The title reaction proceeds in the presence of 5 mol % of the catalyst 1, and is complete within an hour. The 2-alkyl- and 2-aryl-substituted 3-pyrroline products are obtained in good yield and with high enantioselectivity. The application of the method to the concise formal synthesis of (+)-trachelanthamidine is also demonstrated. Boc=tert- butoxycarbonyl, M.S.=molecular sieves, TBDPS=tert-butyldiphenylsilyl. Copyright
