1361407-65-9

Upstream product

• 1275576-22-1 (R)-N-(tert-butoxycarbonyl)-2-amino-3-(p-methyloxyphenyl)-N-methoxy-N-methylpropionamide 
• 1361407-60-4 (3R,4R)-4-[N-(tert-butoxycarbonyl)amino]-5-(4-methoxyphenyl)-3-methylpent-1-en-3-ol 
• 1361407-63-7 (4R,5R)-N-(tert-butoxycarbonyl)-5-ethenyl-4-(4-methoxybenzyl)-5-methyl-1,3-oxazolidin-2-one 
• 27784-76-5 tert-butyl diethylphosphonoacetate 

Downstream Products

• 1361407-69-3 tert-butyl (2R,5R,3E)-5-[N-(tert-butoxycarbonyl)amino]-2-(3-hydroxypropyl)-6-(4-methoxyphenyl)-4-methylhex-3-enoate 
• 1361407-71-7 tert-butyl (2R,5R,3E)-2-{3-[N-[(benzyloxy)carbonyl]-N-[(2-nitrophenyl)sulfonyl]amino]propyl}-5-[N-(tert-butoxycarbonyl)amino]-6-(4-methoxyphenyl)-4-methylhex-3-enoate 
• 1361407-73-9 tert-butyl (2R,5R,3E)-2-{3-[N-(benzyloxycarbonyl)amino]propyl}-5-[N-(tert-butoxycarbonyl)-amino]-6-(4-methoxyphenyl)-4-methylhex-3-enoate 
• 1333081-31-4 (2R,5R,3E)-2-{3-[N-(benzyloxycarbonyl)amino]propyl}-5-[N-(9-fluorenylmethoxycarbonyl)-amino]-6-(4-methoxyphenyl)-4-methylhex-3-enoic acid 
• 1361407-67-1 tert-butyl (2R,5R,3E)-5-[N-(tert-butoxycarbonyl)amino]-2-[3-(tert-butyldimethylsiloxy)-propyl]-6-(4-methoxyphenyl)-4-methylhex-3-enoate 
• 1361407-75-1 tert-butyl (2S,5R,3Z)-5-[N-(tert-butoxycarbonyl)amino]-2-[3-(tert-butyldimethylsiloxy)-propyl]-6-(4-methoxyphenyl)-4-methylhex-3-enoate 

Relevant academic research and scientific papers

Structure-activity relationship study of a CXC chemokine receptor type 4 antagonist, FC131, using a series of alkene dipeptide isosteres

A structure-activity relationship study on a highly potent CXC chemokine receptor type 4 (CXCR4) antagonist, FC131 [cyclo(-d-Tyr1-Arg 2-Arg3-Nal4-Gly5-)], was carried out using a series of alkene isosteres of the d-Tyr1-l/d-Arg2 dipeptide to investigate the binding mode of FC131 and its derivatives with CXCR4. The structure-activity relationships of isostere-containing FC131 analogues were similar to those of the parent FC131 and its derivatives, suggesting that a trans-conformer of the d-Tyr1-Arg2 peptide bond is the dominant contributor to the bioactive conformations of FC131. Although NMR analysis demonstrated that the two conformations of the peptidomimetic containing the d-Tyr1-d-Arg2 isostere are possible, binding-mode prediction indicated that the orientations of the alkene motif within d-Tyr1-MeArg2 peptidomimetics depend on the chirality of Arg2 and the β-methyl group of the isostere unit, which makes the dominant contribution for binding to the receptor. The most potent FC122 [cyclo(-d-Tyr1-d-MeArg2-Arg 3-Nal4-Gly5-)] bound with CXCR4 by a binding mode different from that of FC131.