1361414-72-3Relevant academic research and scientific papers
Hit to lead SAR study on benzoxazole derivatives for an NPY Y5 antagonist
Omori, Naoki,Kouyama, Naoki,Yukimasa, Akira,Watanabe, Kana,Yokota, Yasunori,Tanioka, Hideki,Nambu, Hirohide,Yukioka, Hideo,Sato, Norihito,Tanaka, Yukari,Sekiguchi, Kazutaka,Okuno, Takayuki
, p. 2020 - 2023 (2012/04/05)
We report a hit to lead study on a novel benzoxazole NPY Y5 antagonist. Starting from HTS hit 1, structure-activity relationships were developed. Compound 12 showed reduction of food intake and a tendency to suppress body weight gain over the 21-day experimental period.
