136144-59-7Relevant academic research and scientific papers
Water-Soluble Pd-Imidate Complexes: Broadly Applicable Catalysts for the Synthesis of Chemically Modified Nucleosides via Pd-Catalyzed Cross-Coupling
Gayakhe, Vijay,Ardhapure, Ajaykumar,Kapdi, Anant R.,Sanghvi, Yogesh S.,Serrano, Jose Luis,García, Luis,Pérez, Jose,García, Joaquím,Sánchez, Gregorio,Fischer, Christian,Schulzke, Carola
, p. 2713 - 2729 (2016/04/26)
(Figure Presented) A broadly applicable catalyst system consisting of water-soluble Pd-imidate complexes has been enployed for the Suzuki-Miyaura cross-coupling of four different nucleosides in water under mild conditions. The efficient nature of the catalyst system also allowed its application in developing a microwave-assisted protocol with the purpose of expediting the catalytic reaction. Preliminary mechanistic studies, assisted by catalyst poison tests and stoichiometric tests performed using an electrospray ionization spectrometer, revealed the possible presence of a homotopic catalyst system.
New nucleotide pairs for stable DNA triplexes stabilized by stacking interaction
Mizuta, Masahiro,Banba, Jun-Ichi,Kanamori, Takashi,Tawarada, Ryuya,Ohkubo, Akihiro,Sekine, Mitsuo,Seio, Kohji
supporting information; experimental part, p. 9622 - 9623 (2009/02/04)
New nucleotide pairs applicable to formation of DNA triplexes were developed. We designed oligonucleotides incorporating 5-aryl deoxycytidine derivatives (dC5Ars) and cyclic deoxycytidine derivatives, dCPPP and dCPPI, having an expanded aromatic area, as the second strand. As pairing partners, two types of abasic residues (C3: propylene linker, φ: abasic base) were chosen. It was concluded that, when the 5-aryl-modified cytosine bases paired with the abasic sites in TFOs in a space-fitting manner, the stability of the resulting triplexes significantly increased. The recognition of C3 toward dC5Ars was selective because of the stacking interactions between their aromatic part and the nucleobases flanking the abasic site. These results indicate the potential utility of new nucleotide triplets for DNA triplex formation, which might expand the variety of structures and sequences and might be useful for biorelated fields such as DNA nanotechnologies. Copyright
PALLADIUM CATALYZED COUPLING REACTION FOR THE SYNTHESIS OF C-5 ARYL AND HETEROARYL SUBSTITUTED 2'-DEOXYCYTIDINE
Hassan, Mohamed E.
, p. 1295 - 1299 (2007/10/02)
Cytosine nucleosides substituted at C-5 with differently substituted aryls and heteroaryls have been prepared via a palladium catalyzed reaction utilizing 5-chloromercuri or acetoxymercuri nucleosides and haloarenes or heteroarenes.
