1361452-98-3Relevant academic research and scientific papers
Antiviral activity of 3-methyl-6-(prop-l-en-2-yl)cyclohex-3-ene-l,2-diol and its derivatives against influenza A(HlNl)2009 virus
Ardashov, Oleg V.,Zarubaev, Vladimir V.,Shtro, Anna A.,Korchagina, Dina V.,Volcho, Konstantin P.,Salakhutdinov, Nariman F.,Kiselev, Oleg I.
, p. 375 - 380 (2012/06/01)
A number of new derivatives of monoterpenoid with a para-menthane framework 3-methyl-6-(prop-1-en-2- yl)cyclohex-3-ene-1,2-diol (-)-3 were synthesized. The antiviral activity of (-)-3 and its derivatives against the pandemic influenza virus A/California/07/09 (H1N1)v was studied in vitro. Compound (-)-3 was found to be active against this virus (selectivity index 7.5); for mononicotinate (+)-6 the selectivity index was 17. The absolute configuration of compound 6 was shown to be critical for its antiviral activity.
