13615-15-1

Upstream product

• 321-37-9 4'-chloro-2,2,2-trifluoroacetophenone 
• 1554108-97-2 1-(4-chloro-3-nitrophenyl)-2,2,2-trifluoroethan-1-ol 
• 16588-34-4 4-chloro-3-nitro-benzaldehyde 
• 104-88-1 4-chlorobenzaldehyde 

Downstream Products

• 158401-00-4 1-(3,4,5-trichloro-phenyl)-2,2,2-trifluoro-ethanone 

Relevant academic research and scientific papers

Design and Synthesis of Ligand-Tag Exchangeable Photoaffinity Probe Utilizing Nosyl Chemistry

Construction of a fluorophore or high-sensitive mass tag on target molecules would promise the facile analysis in photoaffinity labeling. A novel 2-nitrobenzenesulfonyl (nosyl; Ns) diazirine, which exhibits bifunctional properties for efficient photoaffinity labeling, was designed. This strategy highlights the simplicity of the chemical probe and its ability to install identification tags via Meisenheimer complex by SNAr after photo-labelling. Herein, in this study, we synthesized new Ns diazirine and demonstrated further studies in terms of photoactivation and SNAr reaction in aqueous condition.

PROCESS FOR THE PREPARATION OF HALO-SUBSTITUTED BENZENES

The present invention relates to a process for the preparation of a compound of formula (I), wherein R1 is hydrogen, fluoro or chloro; which process comprises a) reacting a compound of formula (II), wherein R1 is hydrogen, fluoro or chloro; with a nitration agent to the compound of formula (III), wherein R1 is hydrogen, fluoro or chloro; b) reacting the compound of formula III with a chlorinating agent to the compound of formula (IV), wherein R1 is hydrogen, fluoro or chloro; and c) reacting the compound of formula (III) with chlorine gas at a temperature from 180°C to 250°C to the compound of formula (I).

PROCESS FOR THE PREPARATION OF HALO-SUBSTITUTED TRIFLUOROACETOPHENONES

The invention relates to a process for the preparation of a compound of formula I (I), wherein R1 is hydrogen, fluoro or chloro; which process comprises a) reacting a compound of formula II (II), wherein R1 is hydrogen, fluoro or chloro; with a nitration agent to the compound of formula (III), wherein R1 is hydrogen, fluoro or chloro; and b) reacting the compound of formula III with chlorine gas at temperature from 180°C to 250°C to the compound of formula I.