1361520-66-2

Upstream product

• 1361520-65-1 3-cyano-5-iodo-6-[2-(4-nitrophenyl)ethoxy]-2-pyridinamine 
• 1361520-63-9 N-[3-cyano-5-iodo-2(1H)-pyridonyl]benzamide 
• 1361520-62-8 N-[3-cyano-6-(4-methoxybenzyloxy)-2-pyridinyl]benzamide 
• 1361520-74-2 C₁₉H₁₈N₄O₆ 
• 1361520-73-1 C₃₅H₃₆N₄O₆Si 
• 1361520-61-7 3-cyano-6-(4-methoxybenzyloxy)-2-pyridinamine 
• 52471-07-5 2-amino-6-chloro-3-cyanopyridine 

Downstream Products

• 1361520-69-5 3-cyano-5-(2'-deoxy-3'-O-acetyl-β-D-ribofuranosyl)-N-[(dibutylamino)methylene]-6-[2-(4-nitrophenyl)ethoxy]-2-pyridinamine 
• 1361520-77-5 C₄₀H₃₈N₄O₈ 

Relevant academic research and scientific papers

Synthesis and properties of 5-cyano-substituted nucleoside analog with a donor-donor-acceptor hydrogen-bonding pattern

6-Aminopyridin-2-ones form Watson-Crick pairs with complementary purine analogues to add a third nucleobase pair to DNA and RNA, if an electron-withdrawing group at position 5 slows oxidation and epimerization. In previous work with a nucleoside analogue trivially named dZ, the electron withdrawing unit was a nitro group. Here, we describe an analogue of dZ (cyano-dZ) having a cyano group instead of a nitro group, including its synthesis, pKa, rates of acid-catalyzed epimerization, and enzymatic incorporation.