136155-08-3

Upstream product

• 136155-02-7 2-Acetoxymethyl-3-butenyl acetate 
• 136155-01-6 (R)-2-Hydroxymethyl-3-butenyl acetate 
• 136155-04-9 (S)-2-(tert-Butyldiphenylsilyloxymethyl)-3-butenyl acetate 
• 136155-05-0 2-Acetoxymethyl-3-butynyl acetate 
• 102573-92-2 2-(hydroxymethyl)-3-butyn-1-ol 
• 136155-06-1 (2S,3RS)-2-(tert-Butyldiphenylsilyloxymethyl)-3,4-epoxybutyl acetate 

Downstream Products

• 136155-16-3 (2S,3R,5RS,8R)-2-(tert-Butyldiphenylsilyloxymethyl)-10,10-ethylenedioxy-8-methyl-5-(phenylsulfonyl)undecane-1,3-diol 
• 136155-18-5 (2S,3R,8R)-2-(tert-Butyldiphenylsilyloxymethyl)-10,10-ethylenedioxy-8-methylundecane-1,3-diol 
• 136155-19-6 (4R,9R,10S)-10-(tert-Butyldiphenylsilyloxymethyl)-9,10-isopropylidenedioxy-4-methyl-2-undecanone 
• 136155-21-0 Methyl (7R,12R,13S)-13-(tert-Butyldiphenylsilyloxymethyl)-12,14-isopropylidenedioxy-3,5,7-trimethyltetradeca-2,4-dienoate 

Relevant academic research and scientific papers

Synthetic Microbial Chemistry, XXIV. - Synthesis of Antibiotic 1233A, an Inhibitor of Cholesterol Biosynthesis

A synthesis of 1233A -3,5,7-trimethyl-2,4-undecadienoic acid (1a)> was achieved by employing (R)-2-hydroxymethyl-3-butenyl acetate (2a) and (R)-citronellic acid (3) as chiral building blocks.The former was prepared by lipase-mediated asymmetric hydrolysis of the corresponding diacetate. Key Words: Antibiotic 1233A / Cholesterol biosynthesis, inhibitor of / β-Lactone / Lipase, asymmetric hydrolysis with / Sulfone, alkylation of