1361572-95-3Relevant academic research and scientific papers
Structure-based design of novel class II c-Met inhibitors: 1. Identification of pyrazolone-based derivatives
Norman, Mark H.,Liu, Longbin,Lee, Matthew,Xi, Ning,Fellows, Ingrid,D'Angelo, Noel D.,Dominguez, Celia,Rex, Karen,Bellon, Steven F.,Kim, Tae-Seong,Dussault, Isabelle
, p. 1858 - 1867 (2012/05/05)
Deregulation of c-Met receptor tyrosine kinase activity leads to tumorigenesis and metastasis in animal models. More importantly, the identification of activating mutations in c-Met, as well as MET gene amplification in human cancers, points to c-Met as a
