13616-29-0 Usage
Uses
Used in Pharmaceutical Industry:
GSK837149A is used as an inhibitor for [FASN] for [targeting highly upregulated FASN in tumor cells and cell lines, potentially leading to cancer treatment].
Used in Cancer Research:
GSK837149A is used as a research tool for [studying the role of FASN in cancer cell growth and proliferation, and for identifying potential therapeutic targets in cancer treatment].
Used in Drug Development:
GSK837149A is used as a lead compound for [developing new drugs that target FASN, potentially offering novel treatment options for various types of cancer].
Biochem/physiol Actions
GSK837149A is the first selective inhibitor of human fatty acid synthase (FAS) known to act specifically and selectively on the KR activity of the enzyme. It was first isolated as a minor impurity in a sample found to be active against the enzyme in a high-throughput screening campaign. GSK837149A and its analogs synthesized, all being symmetrical structures containing a bisulfonamide urea, act by inhibiting the beta-ketoacyl reductase activity of the enzyme. GSK837149A inhibits FAS in a reversible mode, with a Ki value of approximately 30 nm, and it possibly binds to the enzyme-ketoacyl-ACP complex. Although initial results suggest that cell penetration for these compounds is impaired, they still can be regarded as useful tools with which to probe and explore the beta-ketoacyl reductase active site in FAS, helping in the design of new inhibitors.
Check Digit Verification of cas no
The CAS Registry Mumber 13616-29-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,3,6,1 and 6 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 13616-29:
(7*1)+(6*3)+(5*6)+(4*1)+(3*6)+(2*2)+(1*9)=90
90 % 10 = 0
So 13616-29-0 is a valid CAS Registry Number.
