136166-33-1

Basic information

• Product Name: Sulfamic acid, 2-phenoxy-1,3-propanediyl ester
• CAS NO: 136166-33-1
• Molecular Formula: C9H14N2O7S2
• Molecular Weight: 326.351
• Mol File: 136166-33-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Sulfamic acid, 2-phenoxy-1,3-propanediyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Sulfamic acid, 2-phenoxy-1,3-propanediyl ester(136166-33-1)
• EPA Substance Registry System: Sulfamic acid, 2-phenoxy-1,3-propanediyl ester(136166-33-1)

Safety Data

• Hazardous Substances Data: 136166-33-1(Hazardous Substances Data)

Upstream product

• 1189-71-5 isocyanate de chlorosulfonyle 
• 16365-26-7 2-(3-nitrophenoxy)ethanol 
• 75-07-0 acetaldehyde 

Relevant articles and documents

Compounds having one or more aminosulfaonyloxy radicals useful as pharmaceuticals

Methods of treating chronic arthritis and osteoporosis which utilize both known and novel compounds which would fall under the general formula:(HO)p--A--[--OS(O) 2 NR 1 R 2 ] zwherein A encompasses a wide range of values including but not limited to aryl, loweralkyl, cycloalkyl, and carbohydrates including sucrose and fructose; p is equal to the number of unreacted hydroxy groups contained on the molecule and may be zero; z is the number of --OS(O) 2 NR 1 R 2 groups and is always at least one; R 1 and R 2 are selected from hydrogen, loweralkyl, carboxy and the like; a novel process for preparing the compounds is provided wherein an appropriate sulfamic acid aryl ester is reacted with a hydroxy substituted A radical which may or may not contain thereon protected carboxyl, amino or hydroxy substituents, in an aprotic solvent containing a tertiary amine base. Pharmaceutical compositions for the treatment of chronic arthritis and osteoporosis are also provided.

Aryl and aryloxyalkyl sulfamate esters useful as anticonvulsants

Herein disclosed is a method of treating convulsions with a pharmaceutical composition containing a compound of the formula: where A is an aryl, arylalkyl, or aryloxyalkyl group and is substituted on 1 or more carbon atoms with a sulfamate group (--OSO2 NR1 R2) wherein R1 and R2, same or different, are hydrogen or loweralkyl wherein p is 0 or 1 and is the number of untreated hydroxyl groups and z is 1 or 2 and is the number of --OS(O2)NR1 R2 groups. Aryl is selected from phenyl, substituted phenyl, pyridinyl, naphthyl, quinolinyl, and the like. Phenyl substituents are selected from hydrogen, halo, hydroxy, phenyl, phenoxy, benzoyl, loweralkyl, loweralkoxy, carboxy, amino, loweralkylamino, diloweralkylamino, acetamido, cyano, nitro, loweralkoxycarboyl, aminosulfonyl, imidazolyl, triazolyl, and the like. Novel compounds not previously disclosed are also described.