136166-42-2

Basic information

• Product Name: Sulfamic acid, 1-[(2-methoxyphenoxy)methyl]-1,2-ethanediyl ester, (R)-
• CAS NO: 136166-42-2
• Molecular Formula: C10H16N2O8S2
• Molecular Weight: 356.378
• Mol File: 136166-42-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Sulfamic acid, 1-[(2-methoxyphenoxy)methyl]-1,2-ethanediyl ester, (R)-(CAS DataBase Reference)
• NIST Chemistry Reference: Sulfamic acid, 1-[(2-methoxyphenoxy)methyl]-1,2-ethanediyl ester, (R)-(136166-42-2)
• EPA Substance Registry System: Sulfamic acid, 1-[(2-methoxyphenoxy)methyl]-1,2-ethanediyl ester, (R)-(136166-42-2)

Safety Data

• Hazardous Substances Data: 136166-42-2(Hazardous Substances Data)

Upstream product

• 7778-42-9 sulphamoyl chloride 
• 61248-76-8 (S)-guaifenesin 

Relevant articles and documents

Sulfamates as antiglaucoma agents

Sulfamate esters of the formula where A is aryloxyalkyl, p is the number of unreacted hydroxy groups present on the alkyl moiety and may be zero, z is the number of --OS(O)2 NR1 R2 groups attached to carbons of the alkyl moiety and is always at least one; R1 and R2 are selected from hydrogen, loweralkyl, carboxy, and the like are useful in treating glaucoma.

Aryl and aryloxyalkyl sulfamate esters useful as anticonvulsants

Herein disclosed is a method of treating convulsions with a pharmaceutical composition containing a compound of the formula: where A is an aryl, arylalkyl, or aryloxyalkyl group and is substituted on 1 or more carbon atoms with a sulfamate group (--OSO2 NR1 R2) wherein R1 and R2, same or different, are hydrogen or loweralkyl wherein p is 0 or 1 and is the number of untreated hydroxyl groups and z is 1 or 2 and is the number of --OS(O2)NR1 R2 groups. Aryl is selected from phenyl, substituted phenyl, pyridinyl, naphthyl, quinolinyl, and the like. Phenyl substituents are selected from hydrogen, halo, hydroxy, phenyl, phenoxy, benzoyl, loweralkyl, loweralkoxy, carboxy, amino, loweralkylamino, diloweralkylamino, acetamido, cyano, nitro, loweralkoxycarboyl, aminosulfonyl, imidazolyl, triazolyl, and the like. Novel compounds not previously disclosed are also described.