13618-87-6

Usage

Uses

Used in Pharmaceutical and Agrochemical Synthesis:
2,3-dihydro-1H-pyrrolizine is used as a key intermediate in the synthesis of various pharmaceuticals and agrochemicals for its ability to contribute to the development of novel compounds with enhanced biological activity.
Used in Research and Development:
In the scientific community, 2,3-dihydro-1H-pyrrolizine serves as a valuable research tool for studying the effects of its structure on biological activity, aiding in the discovery of new mechanisms of action and potential therapeutic applications.
Used in Anticancer Applications:
2,3-dihydro-1H-pyrrolizine is used as a potential anticancer agent due to its demonstrated toxicity to cells. Research is ongoing to explore its effectiveness in targeting cancer cells while minimizing harm to healthy tissues, with the aim of developing new cancer treatments.

Upstream product

• 7223-42-9 1-(prop-2-yn-1-yl)pyrrolidine 
• 251-60-5 3H-pyrrolizine 

Downstream Products

• 107260-22-0 7-Nitro-1,2-dihydropyrrolizine 
• 107260-15-1 5-Nitro-1,2-dihydropyrrolizine 
• 107260-19-5 6-Nitro-1,2-dihydropyrrolizine 

Relevant academic research and scientific papers

Hydrogenation of pyrrolizin-3-ones; New routes to pyrrolizidines

Pyrrolizin-3-ones (e.g.1) can be easily hydrogenated to their hexahydro (pyrrolizidin-3-one) derivatives in the presence of heterogeneous catalysts. Good diastereoselectivity (up to >97:3, depending on catalysts and solvent) can be achieved if the pyrroli

Acetylenes as Potential Antarafacial Components in Concerted Reactions. Formation of Pyrroles from Thermolyses of Propargylamines, of a Dihydrofuran from a Propargylic Ether, and of an Ethylidenepyrrolidine from a β-Amino Acetylene

A thermal cyclization of acetylenic compounds provides evidence for the ability of acetylenic links to act as antarafacial components in processes.The cyclization competes with the normally favored acetylenic retro-ene reaction.Propargylic amines, without substituents whose presence would hinder a tight cyclic transition state, yield intermediate pyrrolines whose subsequent hydrogen elimination affords pyrroles in small amounts.The same process in 2-ethynyltetrahydropyran affords 8-oxabicyclooctane in 35percent yield.A related thermal reaction of N-methyl-3-hexyn-1-amine provides a quantitative transformation to N-methyl-2-ethylidenepyrrolidine in a nominal s + 2a + 2s + 2s> Moebius process, wherein the acetylenic unit is the antarafacial component.Evidence for concertedness in these reactions is discussed.