136181-24-3Relevant academic research and scientific papers
Synthesis of thromboxane B2 via ketalization/ring-closing metathesis
Marvin, Christopher C.,Clemens, Alexander J. L.,Burke, Steven D.
, p. 5353 - 5356 (2008/09/17)
Total synthesis of thromboxane B2 using intermolecular ketalization followed by ring-closing metathesis is reported. Other key steps include a Sharpless asymmetric epoxidation to form an oxirane on the endo face of the bicyclic acetal, epoxide opening using lithioacetonitrile, an allylic alcohol 1,3-transposition, and Mitsunobu lactonization.
