136186-25-9

Basic information

• Product Name: (Z)-2-Cyano-N-(4-cyano-2-methyl-phenyl)-3-hydroxy-3-(4-trifluoromethyl-phenyl)-acrylamide
• CAS NO: 136186-25-9
• Molecular Weight: 371.318
• Mol File: 136186-25-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (Z)-2-Cyano-N-(4-cyano-2-methyl-phenyl)-3-hydroxy-3-(4-trifluoromethyl-phenyl)-acrylamide(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-2-Cyano-N-(4-cyano-2-methyl-phenyl)-3-hydroxy-3-(4-trifluoromethyl-phenyl)-acrylamide(136186-25-9)
• EPA Substance Registry System: (Z)-2-Cyano-N-(4-cyano-2-methyl-phenyl)-3-hydroxy-3-(4-trifluoromethyl-phenyl)-acrylamide(136186-25-9)

Safety Data

• Hazardous Substances Data: 136186-25-9(Hazardous Substances Data)

Upstream product

• 78881-21-7 4-amino-3-methylbenzonitrile 
• 96784-54-2 3-methyl-4-nitrobenzonitrile 
• 329-15-7 4-trifluoromethyl-phenyl acetyl chloride 

Relevant articles and documents

Synthesis and Biological Activity of a Series of Diaryl-Substituted α-Cyano-β-hydroxypropenamides, a New Class of Anthelmintic Agents

A series of α-cyano-β-hydroxypropenamides was prepared and tested for anthelmintic activity. α-Cyano-β-hydroxy-N--3-propenamide (1) showed good activity against the nematode Nematospirodes dubius in a mixed parasite infection in mice; several of the analogues were also effective against the cestode Hymenolepis nana.In sheep trials, 1 caused 100percent reduction of the hematophagous nematode Haemonchus contortus after a single dose of 20 mg/kg but did not show satisfactory control of Trichostrongylus colubriformis or Ostertagia circumcincta.Against the liver fluke Fasciola hepatica, 1 suppressed egg production but only temporarily, suggesting that the adult flukes were not eliminated.Mechanism of action studies on 1 using Ascaris mitochondria showed it to be an uncoupler of oxidative phosphorylation.