1361949-88-3

Basic information

• Product Name: C₁₇H₁₂N₄O₅
• Synonyms: C₁₇H₁₂N₄O₅
• CAS NO: 1361949-88-3
• Molecular Weight: 352.306
• Mol File: 1361949-88-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₇H₁₂N₄O₅(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₇H₁₂N₄O₅(1361949-88-3)
• EPA Substance Registry System: C₁₇H₁₂N₄O₅(1361949-88-3)

Safety Data

• Hazardous Substances Data: 1361949-88-3(Hazardous Substances Data)

Upstream product

• 125520-55-0 3-carboxy-4-phenyl-1,2,5-oxadiazole 2-oxide 
• 1361949-56-5 C₉H₈N₄O₃ 
• 619-66-9 4-Carboxybenzaldehyde 

Relevant articles and documents

Discovery of new orally effective analgesic and anti-inflammatory hybrid furoxanyl N-acylhydrazone derivatives

We report the design, the synthesis and the biological evaluation of the analgesic and anti-inflammatory activities of furoxanyl N-acylhydrazones (furoxanyl-NAH) by applying molecular hybridization approach. Hybrid compounds with IL-8-release inhibition capabilities were identified. Among them, furoxanyl-NAH, 17, and benzofuroxanyl-derivative, 24, together with furoxanyl-NAH derivative, 31, without IL-8 inhibition displayed both orally analgesic and anti-inflammatory activities. These hybrid derivatives do not have additional LOX- or COX-inhibition activities. For instance, LOX-inhibition by furoxanyl-NAH derivative, 42, emerged as a structural lead to develop new inhibitors. The lack of mutagenicity of the active derivatives 17, 31, and 42, allow us to propose them as candidates for further clinical studies. These results confirmed the success in the exploitation of hybridization strategy for identification of novel N-acylhydrazones (NAH) with optimized activities.