1361950-38-0Relevant articles and documents
Cocrystals of lamotrigine based on coformers involving carbonyl group discovered by hot-stage microscopy and DSC screening
Leksic, Edislav,Pavlovic, Gordana,Mestrovic, Ernest
experimental part, p. 1847 - 1858 (2012/06/30)
Four novel lamotrigine cocrystals, namely, 1:1 lamotrigine:phthalimide (1), 1:1:1 lamotrigine:pyromellitic diimide:DMF (2), 2:1:0.64 lamotrigine:caffeine: 3-pentanone (3), and 1:1 lamotrigine:isophthaldehyde (4), were discovered using a combined hot-stage thermomicroscopy and differential-scanning calorimetry screening technique. The utilized cocrystal screening method is rapid, requires the use of small amounts of material, and is highly suitable for compounds that are prone to solvate formation. The structurally characterized cocrystals were prepared in an attempt to develop lamotrigine cocrystals based on cocrystal formers involving carbonyl and amide functional groups. The prepared cocrystals are sustained by N-H(amide)???N(pyridyl), N-H(amino) ???O(amide), and N-H(amino)???O(carbonyl) hydrogen bonds.