1361951-38-3 Usage
Chemical Class
Pyrazolopyrimidine
A class of chemical compounds that includes 2-(4-((3-(3-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-5-yl)amino)-trans-cyclohexyl)propan-2-ol.
Sub类别
Cyclohexylamines
A subcategory of chemical compounds that includes 2-(4-((3-(3-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-5-yl)amino)-trans-cyclohexyl)propan-2-ol, characterized by the presence of a cyclohexyl group and an amine group.
Sub类别
Secondary Alcohols
A subcategory of chemical compounds that includes 2-(4-((3-(3-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-5-yl)amino)-trans-cyclohexyl)propan-2-ol, characterized by the presence of an alcohol (hydroxyl) group attached to a carbon atom that is bonded to only one other carbon atom.
Function
Cyclooxygenase 2 Inhibitor
2-(4-((3-(3-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-5-yl)amino)-trans-cyclohexyl)propan-2-ol acts as a COX-2 inhibitor, which helps in reducing inflammation and pain.
Function
Analgesic
This chemical compound has pain-relieving properties, making it useful for treating conditions that involve pain.
Function
Non-Steroidal Anti-Inflammatory Drug (NSAID)
It is a type of NSAID, which means it is used to reduce inflammation and pain without the use of steroids.
Function
Cyclooxygenase 1 Inhibitor
2-(4-((3-(3-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-5-yl)amino)-trans-cyclohexyl)propan-2-ol also acts as a COX-1 inhibitor, which can help in reducing pain and inflammation.
Function
Xenobiotic
This chemical compound is considered a xenobiotic, meaning it is a foreign substance to the body and may have potential side effects.
Medical Uses
Pain Relief
It is used to relieve pain in various conditions, such as arthritis, menstrual cramps, and minor aches and pains.
Medical Uses
Inflammation Reduction
The compound helps in reducing inflammation, which can be beneficial in treating conditions like arthritis.
Side Effects
Gastrointestinal Bleeding
Potential side effects of 2-(4-((3-(3-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-5-yl)amino)-trans-cyclohexyl)propan-2-ol include an increased risk of gastrointestinal bleeding.
Side Effects
Cardiovascular Risks
The use of this chemical compound may be associated with increased cardiovascular risks.
Check Digit Verification of cas no
The CAS Registry Mumber 1361951-38-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,6,1,9,5 and 1 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1361951-38:
(9*1)+(8*3)+(7*6)+(6*1)+(5*9)+(4*5)+(3*1)+(2*3)+(1*8)=163
163 % 10 = 3
So 1361951-38-3 is a valid CAS Registry Number.
1361951-38-3Relevant academic research and scientific papers
Substituted imidazo[1,2-b]pyridazines as protein kinase inhibitors
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Page/Page column 162; 163; 165; 166, (2016/09/13)
The present invention provides protein kinase having one of the following structures (I), (II) or (III): or a stereoisomer, prodrug, tautomer or pharmaceutically acceptable salt thereof, wherein R, R1, R2 and X are as defined herein. Compositions and methods for using the same in the treatment of cancer, autoimmune, inflammatory and other Pim kinase-associated conditions are also disclosed.
Synthesis and biological evaluation of pyrazolo[1,5- A ]pyrimidine compounds as potent and selective pim-1 inhibitors
Xu, Yong,Brenning, Benjamin G.,Kultgen, Steven G.,Foulks, Jason M.,Clifford, Adrianne,Lai, Shuping,Chan, Ashley,Merx, Shannon,McCullar, Michael V.,Kanner, Steven B.,Ho, Koc-Kan
, p. 63 - 67 (2015/01/30)
Pim-1 has emerged as an attractive target for developing therapeutic agents for treating disorders involving abnormal cell growth, especially cancers. Herein we present lead optimization, chemical synthesis and biological evaluation of pyrazolo[1,5-a]pyri
HETEROCYCLIC PROTEIN KINASE INHIBITORS
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Paragraph 00426; 00427; 00428; 00430, (2013/03/26)
The present invention provides protein kinase having one of the following structures (I), (II) or (III): or a stereoisomer, prodrug, tautomer or pharmaceutically acceptable salt thereof, wherein R, R1, R2 and X are as defined herein. Compositions and methods for using the same in the treatment of cancer, autoimmune, inflammatory and other Pim kinase-associated conditions are also disclosed.
