1361951-79-2Relevant academic research and scientific papers
Substituted imidazo[1,2-b]pyridazines as protein kinase inhibitors
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, (2016/09/13)
The present invention provides protein kinase having one of the following structures (I), (II) or (III): or a stereoisomer, prodrug, tautomer or pharmaceutically acceptable salt thereof, wherein R, R1, R2 and X are as defined herein. Compositions and methods for using the same in the treatment of cancer, autoimmune, inflammatory and other Pim kinase-associated conditions are also disclosed.
Synthesis and biological evaluation of pyrazolo[1,5- A ]pyrimidine compounds as potent and selective pim-1 inhibitors
Xu, Yong,Brenning, Benjamin G.,Kultgen, Steven G.,Foulks, Jason M.,Clifford, Adrianne,Lai, Shuping,Chan, Ashley,Merx, Shannon,McCullar, Michael V.,Kanner, Steven B.,Ho, Koc-Kan
supporting information, p. 63 - 67 (2015/01/30)
Pim-1 has emerged as an attractive target for developing therapeutic agents for treating disorders involving abnormal cell growth, especially cancers. Herein we present lead optimization, chemical synthesis and biological evaluation of pyrazolo[1,5-a]pyri
HETEROCYCLIC PROTEIN KINASE INHIBITORS
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Paragraph 00407; 00408, (2013/03/26)
The present invention provides protein kinase having one of the following structures (I), (II) or (III): or a stereoisomer, prodrug, tautomer or pharmaceutically acceptable salt thereof, wherein R, R1, R2 and X are as defined herein. Compositions and methods for using the same in the treatment of cancer, autoimmune, inflammatory and other Pim kinase-associated conditions are also disclosed.
