1361962-46-0Relevant academic research and scientific papers
Efficient synthesis of carbazoles via PtCl2-catalyzed RT cyclization of 1-(indol-2-yl)-2,3-allenols: Scope and mechanism
Kong, Wangqing,Fu, Chunling,Ma, Shengming
experimental part, p. 2164 - 2173 (2012/04/11)
A detailed study on the scope of the efficient PtCl2-catalyzed synthesis of carbazoles from 1-(indol-2-yl)-2,3-allenols is described. Through isotopic labeling experiments, it is confirmed that the reaction proceeds through a unique metal carbene intermediate, which undergoes subsequent highly selective 1,2-hydrogen migration to afford carbazoles. The reaction shows wide scope and allows the introduction of a variety of different substituents at different positions on the carbazole due to the substituent-loading capability of both indole and the allene moiety.
