1361963-73-6Relevant academic research and scientific papers
Unified approach to isoindolinones and THIQs via lewis acid catalyzed domino mukaiyama-mannich Lactamization/Alkylations: Application in the synthesis of (±)-homolaudanosine
Dhanasekaran, Sivasankaran,Kayet, Anirban,Suneja, Arun,Bisai, Vishnumaya,Singh, Vinod K.
, p. 2780 - 2783 (2015)
A novel and efficient synthesis of a variety of isoindolinones and tetrahydroisoquinolines via a Lewis acid catalyzed domino Mukaiyama-Mannich lactamization/alkylation is achieved. This transformation comprises a sequential formation of three new bonds through a one-pot, three-component procedure to afford product in moderate to high yields. A concise synthesis of (±)-homolaudanosine (2b) has been achieved using this method.
One-pot synthesis of isoindolinones via three-component Mannich/lactamization cascade reaction
Zhang, Haoyi,Leng, Yixin,Liu, Wenjing,Duan, Wenhu
experimental part, p. 1115 - 1127 (2012/04/04)
An efficient synthesis of 3-substituted 2,3-dihydroisoindolin-1-ones was achieved with good yields (up to 88%). The process features broad substrate scope, high efficiency, and simplicity, using an one-pot, three-component Mannich/lactamization cascade reaction in the absence or presence of p-toluenesulfonic acid. Copyright Taylor & Francis Group, LLC.
