1361964-64-8Relevant academic research and scientific papers
Enantioselective, Aerobic Copper-Catalyzed Intramolecular Carboamination and Carboetherification of Unactivated Alkenes
Carmo, Raul L. L.,Chemler, Sherry R.,Galster, Samuel L.,Wdowik, Tomasz
, p. 8535 - 8541 (2020/09/21)
Reduction of waste is an important goal of modern organic synthesis. We report herein oxidase reactivity for enantioselective intramolecular copper-catalyzed alkene carboamination and carboetherification reactions where previously used stoichiometric MnO2
Generation and Reactivity of Amidyl Radicals: Manganese-Mediated Atom-Transfer Reaction
Li, Jinxia,Li, Ping,Liu, Run-Zhou,Liu, Xian-Guan,Qu, Shuanglin,Sun, Jun,Zhang, Bo
supporting information, p. 4428 - 4433 (2020/02/05)
A simple and efficient protocol to generate amidyl radicals from amine functionalities through a manganese-mediated atom-transfer reaction has been developed. This approach employs an earth-abundant and inexpensive manganese complex, Mn2(CO)su
Direct Synthesis of 2-Formylpyrrolidines, 2-Pyrrolidinones and 2-Dihydrofuranones via Aerobic Copper-Catalyzed Aminooxygenation and Dioxygenation of 4-Pentenylsulfonamides and 4-Pentenylalcohols
Wdowik, Tomasz,Chemler, Sherry R.
supporting information, p. 9515 - 9518 (2017/07/25)
A new method for the direct conversion of 4-pentenylsulfonamides to 2-formylpyrrolidines and a 2-ketopyrrolidine has been developed. This transformation occurs via aerobic copper-catalyzed alkene aminooxygenation where molecular oxygen serves as both oxidant and oxygen source. The 2-formylpyrrolidines can further undergo oxidative carbon-carbon bond cleavage in situ upon addition of DABCO, providing 2-pyrrolidinones. These transformations have been demonstrated for a range of 4-pentenylsulfonamides. 4-Pentenylalcohols also undergo oxidative cyclization to form γ-lactones predominantly. The reaction is chemoselective, oxidizing one alkene in the presence of others, and is compatible with several functional groups. Application of these reactions to the formal syntheses of baclofen and (+)-monomorine was demonstrated.
Regioselective (Diacetoxyiodo)benzene-promoted halocyclization of unfunctionalized olefins
Liu, Gong-Qing,Li, Yue-Ming
, p. 10094 - 10109 (2015/02/19)
A metal-free method for intramolecular halocyclization of unfunctionalized olefins was detailed. (Diacetoxyiodo)benzene (PIDA) was very effective for haloamidation, haloetherification, and halolactonization of unfunctionalized olefins. In the presence of
Highly selective palladium-catalyzed intramolecular chloroamination of unactivated alkenes by using hydrogen peroxide as an oxidant
Yin, Guoyin,Wu, Tao,Liu, Guosheng
experimental part, p. 451 - 455 (2012/02/15)
Cheap and clean! A novel Pd-catalyzed oxidative intramolecular chloroamination of unactivated alkenes has been developed by using hydrogen peroxide as an oxidant and CaCl2 as a chlorine source. A series of chlorinated piperidine derivatives has
