1362-14-7 Usage
Description
Vindolicine, a minor constituent of Vinca rosea L., is a dimorphic compound with a double melting point. It is laevorotatory with a specific rotation of [α]26D 48.4° and exhibits an ultraviolet spectrum with absorption maxima at 212, 257, and 308 mμ.
Uses
Used in Pharmaceutical Industry:
Vindolicine is used as an anticancer agent for its potential to inhibit tumor growth and progression. It is particularly effective against various types of solid malignancies, such as liver, breast, lung, pancreatic, colorectal, and ovarian cancers. Vindolicine modulates several oncological signaling pathways, including JAK/STAT, RAS/RAF/mTOR, TGF-β1/TGF-β1R, VEGF/VEGFR, and CXCL12/CXCR4 axes, exerting inhibitory effects on tumor growth and progression.
Additionally, vindolicine demonstrates synergistic anticancer effects when combined with conventional chemotherapeutic drugs, enhancing chemo-sensitivity and efficacy in resistant cases.
Used in Drug Delivery Systems:
To overcome the limitations of vindolicine, novel drug delivery systems have been developed to enhance its applications and efficacy against cancer cells. Various organic and metallic nanoparticles have been employed as carriers for vindolicine delivery, aiming to improve its delivery, bioavailability, and therapeutic outcomes.
References
Svoboda et al., J. Pharm. Sci., 50,409 (1961)
Check Digit Verification of cas no
The CAS Registry Mumber 1362-14-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,3,6 and 2 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1362-14:
(6*1)+(5*3)+(4*6)+(3*2)+(2*1)+(1*4)=57
57 % 10 = 7
So 1362-14-7 is a valid CAS Registry Number.
InChI:InChI=1/C51H64N4O12/c1-11-46-15-13-19-54-21-17-48(38(46)54)32-24-30(36(62-7)26-34(32)52(5)40(48)50(60,44(58)64-9)42(46)66-28(3)56)23-31-25-33-35(27-37(31)63-8)53(6)41-49(33)18-22-55-20-14-16-47(12-2,39(49)55)43(67-29(4)57)51(41,61)45(59)65-10/h13-16,24-27,38-43,60-61H,11-12,17-23H2,1-10H3
