136206-68-3Relevant academic research and scientific papers
The titanium tetrachloride induced synthesis of N-phosphinoylimines and N-sulphonylimines directly from aromatic aldehydes
Jennings, W. Brian,Lovely, Carl J.
, p. 5561 - 5568 (2007/10/02)
The reaction of phosphinic amides or sulphonamides with an aromatic aldehyde in the presence of titanium tetrachloride and triethylamine provides a simple, one-step preparation of N-phosphinoylimines (5a-e) and N-sulphonylimines (7a-g). The extension of this reaction to ketones failed to give the desired imines, the aldol condensation products were obtained instead. The reaction of (+)-camphor with phosphinic amides or sulphonamides in refluxing toluene in the presence of titanium tetrachloride and triethylamine affords the (-)-camphorphosphinoyl- and (-)-camphorsulphonylimines in moderate yield.
HIGHLY DIASTEREOSELECTIVE REDUCTIONS OF N-DIPHENYLPHOSPHINYL IMINES. SYNTHESIS OF AXIAL PRIMARY CYCLIC AMINES.
Hutchins, Robert O.,Rutledge, Melvin C.
, p. 5619 - 5622 (2007/10/02)
The reduction of N-diphenylphosphinyl imines of substituted cycloalkanones with lithium tri-sec-butylborohydride provides highly diastereoselective conversions to protected axial primary amines which are demasked via cleavage with acid.
