1362101-12-9

Upstream product

• 1362100-89-7 (+/-)-N-[2-(3,4-dimethoxyphenyl)ethyl]-N-[2-hydroxy-2-(1H-tetrazol-5-yl)propyl]benzenesulfonamide 
• 1362100-77-3 (+/-)-N-[2-(1-allyl-1H-tetrazol-5-yl)-2-hydroxypropyl]-N-[2-(3,4-dimethoxyphenyl)ethyl]benzenesulfonamide 
• 1362100-05-7 N-[2-(3,4-dimethoxyphenyl)-ethyl]-N-prop-2-ynylbenzenesulfonamide 

Relevant academic research and scientific papers

Synthesis of five-membered unsaturated compounds from ketones via cyanophosphates under neutral conditions: [1,5]-C–H insertion of alkylidene carbenes generated by tetrazole fragmentation

Cyanophosphates (CPs) can easily be prepared via the reactions of carbonyl compounds with diethyl phosphorocyanidate (DEPC) in the presence of LiCN (cat.) under non-aqueous conditions. Treatment of ketone-derived CPs with TMSN3/Bu2Sn

Dehydrative fragmentation of 5-hydroxyalkyl-1 h -tetrazoles: A mild route to alkylidenecarbenes

The development of a mild, base-free method for the generation of alkylidenecarbenes is reported. Treatment of 5-hydroxyalkyl-1H-tetrazoles with carbodiimides generates products arising from the 1,2-rearrangement or [1,5]-C-H bond insertion of a putative alkylidenecarbene. Formation of this divalent intermediate is proposed to occur by way of a tetraazafulvene, which undergoes extrusion of 2 mol of dinitrogen. Details of this methodology, its application to the synthesis of combretastatin A-4, and an improved route to 5-hydroxyalkyl-1H-tetrazoles are described.