1362101-24-3

Upstream product

• 621-59-0 isovanillin 
• 76457-32-4 1-N-allyltetrazole 
• 1362101-22-1 (4-methoxy-3-(2-methoxyethoxymethoxy)phenyl)(3,4,5-trimethoxyphenyl)methanone 
• 1362101-20-9 (+/-)-[4-methoxy-3-(2-methoxyethoxymethoxy)phenyl]-(3,4,5-trimethoxyphenyl)methanol 
• 83088-21-5 3-(β-methoxyethoxymethyloxy)-4-methoxybenzaldehyde 

Downstream Products

• 1362101-26-5 (+/-)-[4-methoxy-3-(2-methoxyethoxymethoxy)phenyl]-(1H-tetrazol-5-yl)(3,4,5-trimethoxyphenyl)methanol 
• 1362101-28-7 5-(2-(3-((2-methoxyethoxy)methoxy)-4-methoxyphenyl)ethynyl)-1,2,3-trimethoxybenzene 
• 1362101-30-1 (Z)-5-(3-((2-methoxyethoxy)methoxy)-4-methoxystyryl)-1,2,3-trimethoxybenzene 
• 117048-62-1 combrestatin A₄ 

Relevant academic research and scientific papers

Dehydrative fragmentation of 5-hydroxyalkyl-1 h -tetrazoles: A mild route to alkylidenecarbenes

The development of a mild, base-free method for the generation of alkylidenecarbenes is reported. Treatment of 5-hydroxyalkyl-1H-tetrazoles with carbodiimides generates products arising from the 1,2-rearrangement or [1,5]-C-H bond insertion of a putative alkylidenecarbene. Formation of this divalent intermediate is proposed to occur by way of a tetraazafulvene, which undergoes extrusion of 2 mol of dinitrogen. Details of this methodology, its application to the synthesis of combretastatin A-4, and an improved route to 5-hydroxyalkyl-1H-tetrazoles are described.