1362243-68-2Relevant academic research and scientific papers
A trifluorinated thiazoline scaffold leading to pro-apoptotic agents targeting prohibitins
Pérez-Perarnau, Alba,Preciado, Sara,Palmeri, Claudia Mariela,Moncunill-Massaguer, Cristina,Iglesias-Serret, Daniel,González-Gironès, Diana M.,Miguel, Miriam,Karasawa, Satoki,Sakamoto, Satoshi,Cosialls, Ana M.,Rubio-Pati?o, Camila,Saura-Esteller, José,Ram?n, Rosario,Caja, Laia,Fabregat, Isabel,Pons, Gabriel,Handa, Hiroshi,Albericio, Fernando,Gil, Joan,Lavilla, Rodolfo
, p. 10150 - 10154 (2015/03/31)
A new class of small molecules, with an unprecedented trifluorothiazoline scaffold, were synthesized and their pro-apoptotic activity was evaluated. With an EC50 in the low micromolar range, these compounds proved to be potent inducers of apopt
Mono- and trifluorination of the thiazole ring of 2,5-diarylthiazoles using N-fluorobenzenesulfonimide (NFSI)
Hatfield, Julie M.,Eidell, Cheryl K.,Stephens, Chad E.
, p. 1025 - 1028 (2013/02/25)
Fluorination of select 2,5-diarylthiazoles using the N-F reagent N-fluorobenzenesulfonimide (NFSI) has led to the formation of both the anticipated 4-fluorothiazole as well as a unique 4,4,5-trifluorothiazole. Selective monofluorination is best achieved using bromobenzene as solvent at 155 °C, while trifluorination is best achieved by performing the reaction without solvent at 135-140 °C. An X-ray crystal structure has been obtained on one of the trifluorinated products.
