1362310-06-2Relevant academic research and scientific papers
Azepine compd. or its salt, asymmetric catalyst, and a method for producing an optically active compd.
-
Paragraph 0094; 0104, (2016/12/22)
PROBLEM TO BE SOLVED: To provide a method for producing a novel azepine compound, an asymmetric catalyst useful in synthesis of an optically active compound by asymmetric reaction, and the optically active compound useful in the field of medicines, agricultural chemicals, and high functional materials in high yield and with high optical purity.SOLUTION: This method for producing the optically active compound includes, under the presence of the azepine compound represented by formula (II), carrying out asymmetric aldol reaction, asymmetric Mannich addition reaction, asymmetric halogenation reaction, asymmetric aminoxylation reaction, asymmetric hydroxyamination reaction or asymmetric conjugate addition reaction.
Powerful amino diol catalyst for effecting the direct asymmetric conjugate addition of aldehydes to acrylates
Kano, Taichi,Shirozu, Fumitaka,Akakura, Matsujiro,Maruoka, Keiji
supporting information, p. 16068 - 16073 (2012/10/29)
Di-tert-butyl methylenemalonate (1) could be employed as a reactive equivalent of a three-carbon Michael acceptor such as acrylate in a direct asymmetric conjugate addition of aldehydes catalyzed by an axially chiral amino diol (S)-3a. Furthermore, acrylate, an unexplored and challenging substrate in enamine catalysis, has also been successfully employed in asymmetric conjugate addition reaction. Relatively inert acrylate is doubly activated by polyfluoroalkyl group of 2 and the hydroxyl group on the axially chiral amino diol catalyst (S)-3b, giving corresponding conjugate adducts in high yield with excellent enantiomeric excess. The obtained conjugate addition products were readily converted to synthetically useful and important chiral building blocks.
