1362426-34-3Relevant academic research and scientific papers
Vasoactive thiomethyl-pyrimidines: Promising drug candidates with vascular activity
De Andrade, Audrey N.,Araújo, Alice V.,Barbosa, Hugo B.W.,Wanderley, Almir G.,Malta, Oscar L.,Dos Anjos, Janaína V.
, p. 1266 - 1273 (2017)
Pyrimidines and their derivatives are present in various biologically active molecules. Most of the synthetic methods employed to achieve the pyrimidinone ring consist of two stages: The synthesis of a Michael intermediate from an aldehyde and an "active
Novel pyrimidinone derivatives: Synthesis, antitumor and antimicrobial evaluation
Taher, Azza,Helwa, Amira Atef
, p. 521 - 530 (2012/06/01)
Starting from 6-aryl-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5- carbonitrile (4a-d), a series of mono- and dialkyl derivatives 5a-j and 6a, b was synthesized. Hydrazinolysis of 4a, b, d and 5d afforded the hydrazino derivatives 7a-c which were cyclised to give the triazolopyrimidinones 8a-c and the pyrimidotriazinones 9a-c through the reaction with formic acid and chloroacetyl chloride, respectively. Most of the newly synthesized compounds were evaluated for their in-vitro antitumor activity. Compounds 6a and b displayed promising anticancer activity against leukaemia, non-small cell lung, melanoma, and renal cancer. On the other hand, all compounds prepared were screened for their in-vitro antibacterial and antifungal activities. Compounds 5h and j showed significant activity against Staphylococcus aureus, while compounds 5e, 7c and 8c displayed moderate inhibitory activity against Candida albicans.
An efficient and facile synthesis of inhibitors for hepatitis C viral and anti-SARS agents: 4-aryl-5-cyano-1,6-dihydro-2-thiouracils
Rong, Liangce,Yin, Shan,Xia, Sheng,Tao, Shimin,Shi, Yanhui,Tu, Shujiang
experimental part, p. 983 - 993 (2012/08/07)
One-pot, multicomponent reaction for the synthesis of 4-aryl-5-cyano-1,6- dihydro-2-thiouracils via three-component from aromatic aldehydes, ethyl 2-cyanoacetate and S-benzylisothiourea hydrochloride (methyl carbamimidothioate sulfate) under methanol is d
