136272-32-7Relevant academic research and scientific papers
AROMATIC FLUORINE CHEMISTRY. PART 4. PREPARATION OF 2,6-DIFLUOROANILINE
Pews, R. G.,Gall, J. A.
, p. 307 - 316 (2007/10/02)
The preparation of 2,6-difluoroaniline from 1,3,5-trichlorobenzene is described. 1-Chloro-3,5-difluorobenzene prepared via KF exchange on 1,3,5-trichlorobenzene is dichlorinated and nitrated in a single reactor to a mixture of trichlorodifluoronitrobenzenes.The latter are reduced to ca. 4:1 mixture of 2,6-difluoroaniline and 2,4-difluoroaniline.
Process and intermediates for the preparation of 2,6-difluoroaniline
-
, (2008/06/13)
1-Chloro-3,5-difluorobenzene is chlorinated to give 4,6-difluoro-1,2,3-trichlorobenzene which in turn is nitrated and reduced to the corresponding novel aniline, 2,6-difluoro-3,4,5-trichloroaniline. Further reduction of this aniline provides 2,6-difluoroaniline with high selectivity.
