136274-57-2 Usage
Uses
Used in Pharmaceutical Industry:
(R,R'')-2,2''-Bis(diphenylphosphino)-1,1''-biferrocene is used as a catalyst in the pharmaceutical industry for asymmetric hydrogenations. Its application is crucial for the synthesis of chiral pharmaceutical compounds, which often exhibit different biological activities and are essential for the development of new drugs with improved efficacy and reduced side effects.
Used in Chemical Synthesis:
In the field of chemical synthesis, (R,R'')-2,2''-Bis(diphenylphosphino)-1,1''-biferrocene is used as a catalyst for asymmetric hydrogenations. This application is vital for the production of enantiomerically pure compounds, which are essential in various industries, including agrochemicals, fragrances, and specialty chemicals.
Used in Research and Development:
(R,R'')-2,2''-Bis(diphenylphosphino)-1,1''-biferrocene is also utilized in research and development settings, where it serves as a valuable tool for studying the mechanisms of asymmetric catalysis and the development of new catalytic systems. Its unique structure and properties make it an attractive candidate for exploring novel reaction pathways and improving the efficiency of existing processes.
Overall, (R,R'')-2,2''-Bis(diphenylphosphino)-1,1''-biferrocene is a versatile organometallic catalyst with significant applications in various industries, particularly in the synthesis of chiral compounds and the development of new catalytic systems. Its use in asymmetric hydrogenations has the potential to impact the pharmaceutical, chemical, and research sectors, contributing to the advancement of science and technology.
Check Digit Verification of cas no
The CAS Registry Mumber 136274-57-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,6,2,7 and 4 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 136274-57:
(8*1)+(7*3)+(6*6)+(5*2)+(4*7)+(3*4)+(2*5)+(1*7)=132
132 % 10 = 2
So 136274-57-2 is a valid CAS Registry Number.
136274-57-2Relevant academic research and scientific papers
Synthesis, coordination behaviour, structural features and use in asymmetric hydrogenations of bifep-type biferrocenes
Espino, Gustavo,Xiao, Li,Puchberger, Michael,Mereiter, Kurt,Spindler, Felix,Manzano, Blanca R.,Jalon, Felix A.,Weissensteiner, Walter
, p. 2751 - 2763 (2009/06/28)
A protocol for the synthesis of C2- and C1-symmetric 2,2″-diarylphosphino-substituted biferrocenes (bifep-type ligands) is presented and the preparation of four representatives is described [(S p,Sp)-2-R12P-2″- R 22P-1,1″-biferrocene; 1 (bifep): R1 = R2 = Ph; 2: R1 = Ph, R2 = Cy; 3: R1 = R2 = 3,5-Me2C6H3; 4: R1 = 3,5-Me2-4-OMe-C6H2, R2 = 3,5-(CF3)2C6H3]. In addition, the synthesis of three palladium(ii) complexes ([PdX2(L)], 10: L = 1, X = Cl; 11: L = 4, X = Cl; 12: L = 1, X = C6F5 and of four bifep ruthenium complexes (13: [RuCl(p-cymene)(1)]PF6; 14: [RuI(p-cymene)(1)]PF6; 15: [RuCl(benzene)(1)]PF6; 16: [RuI(p-cymene)(1)]I) is reported. In the solid state the biferrocene unit of complexes 10, 11 and 15 adopt either a (P)-shaped (10) or an (M)-shaped (11, 15) conformation. In solution, palladium complexes 10 and 11 are present as equilibrium mixtures of rapidly interconverting (P)- and (M)-shaped conformers. Rhodium- and iridium-mediated asymmetric hydrogenations of a number of olefins and one imine give products with only low to moderate enantiomeric excess, while in the ruthenium-catalyzed hydrogenation of ketones a maximum e.e. of 82% is obtained. The low enantioselectivities are assumed to be related to the conformational flexibility of bifep-type ligands.
